Sexual Health

Sildenafil (Generic Viagra®)

What is Sildenafil?

Sildenafil is a medication used primarily to treat erectile dysfunction (ED) in men and, in some cases, pulmonary arterial hypertension (PAH). It is known commercially under the name Viagra®, among others. Sildenafil belongs to a class of medications called phosphodiesterase type 5 (PDE5) inhibitors.

How Does Sildenafil Work?

Sildenafil works by relaxing the blood vessels in the penis, allowing for greater blood flow during sexual arousal. It works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which breaks down cyclic guanosine monophosphate (cGMP). cGMP is a substance that is produced in response to sexual stimulation and that facilitates smooth muscle relaxation and vasodilation in the penis. By inhibiting PDE5, sildenafil allows cGMP to build up, facilitating an erection.

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Indications for Use

  1. Erectile Dysfunction (ED):
    • Use: Sildenafil is taken as needed, approximately 30 minutes to 1 hour before sexual activity. It should not be taken more than once a day.
    • Dosage: Common doses are 25 mg, 50 mg and 100 mg. The recommended starting dose is 50 mg, but may be adjusted depending on the patient's response and side effects.
  2. Pulmonary Arterial Hypertension (PAH):
    • Use: For the treatment of PAH, sildenafil is taken regularly, usually three times a day.
    • Dosage: Recommended doses vary and should be prescribed by a physician based on the patient's specific needs.

Side Effects

Like all medicines, Sildenafil can cause side effects. Common side effects include:

  • Headache
  • Facial redness
  • Indigestion
  • Nasal congestion
  • Blurred vision or changes in color vision (seeing objects with a blue tint)

Serious Side Effects:

  • Erection that is painful or lasts longer than 4 hours (priapism)
  • Sudden loss of vision in one or both eyes (a rare problem called non-arteritic anterior ischaemic optic neuropathy)
  • Sudden hearing loss or ringing in the ears
  • Dizziness or fainting

Contraindications and Precautions

Sildenafil should not be used by people who:

  • Take nitrates for chest pain or heart problems, as the combination can cause a dangerous drop in blood pressure.
  • Are allergic to sildenafil or any of its ingredients
  • Have serious heart problems or have had a recent stroke or heart attack.
  • Have low blood pressure or uncontrolled high blood pressure

Interactions with Other Medications

Sildenafil may interact with other medications, which may increase the risk of serious side effects:

  • Nitrates: Concurrent use may cause a severe drop in blood pressure.
  • Alpha blockers: It may cause postural hypotension (low blood pressure when standing).
  • Other medications for erectile dysfunction: It should not be combined with other treatments for ED.
  • Protease inhibitors for HIV: They can increase levels of sildenafil in the blood, increasing the risk of side effects.

How to Take Sildenafil

For erectile dysfunction:

  • Take it approximately 30 minutes to 1 hour before sexual activity.
  • Do not take it more than once a day.
  • It can be taken with or without food, although fatty foods may delay its action.

For pulmonary arterial hypertension:

  • Follow your doctor's instructions.
  • It is usually taken three times a day with evenly spaced doses.

Conclusion

Sildenafil is an effective medication for the treatment of erectile dysfunction and pulmonary arterial hypertension when used correctly. If you experience erection problems or have PAH, consult a healthcare professional to determine if sildenafil is right for you. At Dzeus, we offer confidential consultations and personalized treatments to help you manage these conditions and improve your quality of life.