Venlafaxine XR

What is Venlafaxine XR?

Venlafaxine is used to treat depression. Venlafaxine extended-release (long-acting) capsules are also used to treat generalized anxiety disorder (GAD; excessive worrying that is difficult to control), social anxiety disorder (extreme fear of interacting with others or performing in front of others that interferes with normal life), and panic disorder (sudden, unexpected attacks of extreme fear and worry about these attacks). Venlafaxine is in a class of medications called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). It works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance.

How should this medicine be used?

Venlafaxine comes as a tablet or extended-release capsule to take by mouth. The tablet is usually taken two or three times a day with food. The extended-release capsule is usually taken once daily in the morning or evening with food. Take venlafaxine at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take venlafaxine exactly as directed. Do not take more or less of it or take it more often or for a longer period of time than prescribed by your doctor.

Swallow the extended-release capsule whole; do not split, chew, or crush it, or place it in water. If you cannot swallow the extended-release capsule, you may carefully open the capsule and sprinkle the entire contents on a spoonful of applesauce. Swallow (without chewing) this mixture immediately after preparation and then drink a glass of water to make sure that you have swallowed all of the medication.

Your doctor will probably start you on a low dose of venlafaxine and gradually increase your dose, not more often than once every 4 to 7 days. Tell your doctor how you are feeling during your treatment so that your doctor can adjust your dose properly.

Venlafaxine controls depression but does not cure it. It may take several weeks or longer for you to feel the full benefit of this medication. Continue to take venlafaxine even if you feel well. Do not stop taking venlafaxine without talking to your doctor. Your doctor will probably decrease your dose gradually. If you suddenly stop taking venlafaxine, you may experience withdrawal symptoms such as agitation; anxiety; tiredness; confusion; mood changes; headache; dizziness; irritability; frenzied or abnormal excitement; lack of coordination; trouble falling asleep or staying asleep; nightmares; nausea; vomiting; loss of appetite; diarrhea; dry mouth; sweating; uncontrollable shaking of a part of the body; ringing in the ears; blurred vision; seizures; or burning, tingling, numbness, or electric shock-like feelings in any part of the body. Tell your doctor if you experience any of these symptoms while you are decreasing your dose of venlafaxine or soon after you stop taking venlafaxine.

What special precautions should I follow?

Before taking venlafaxine,

• tell your doctor and pharmacist if you are allergic to venlafaxine, any other medications, or any of the ingredients in venlafaxine tablets or extended-release capsules. Ask your pharmacist for a list of the ingredients.
• you should know that desvenlafaxine is very similar to another SNRI, desvenlafaxine (Pristiq). You should not take these medications together.
• tell your doctor or pharmacist if you are taking the following medications or have stopped taking them within the past two weeks:monoamine oxidase (MAO) inhibitor, such as isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate). If you stop taking venlafaxine, your doctor will tell you that you should wait at least 7 days before you start to take an MAO inhibitor.
• some medications should not be taken with venlafaxine. Other medications may cause dosing changes or extra monitoring when taken with venlafaxine. Make sure you have discussed any medications you are currently taking or plan to take before starting venlafaxine with your doctor and pharmacist. Before starting, stopping, or changing any medications while taking venlafaxine, please get the advice of your doctor or pharmacist.
• the following nonprescription or herbal products may interact with venlafaxine: St. John's wort; tryptophan; cimetidine (Tagamet). Be sure to let your doctor and pharmacist know that you are taking these medications before you start taking venlafaxine. Do not start any of these medications while taking venlafaxine without discussing with your healthcare provider.
• tell your doctor if you have ever used illegal drugs or overused prescription medications. Also tell your doctor if you have recently had a heart attack and if you have or have ever had high blood pressure, high blood cholesterol seizures, glaucoma (increased pressure in the eye that may cause loss of sight), or heart, kidney, liver, or thyroid disease.
• tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breast-feeding. If you become pregnant while taking venlafaxine, call your doctor. Venlafaxine may cause problems in newborns following delivery if it is taken during the last months of pregnancy.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking venlafaxine.
• you should know that this medication may make you drowsy and may affect your judgment, thinking, and movements. Do not drive a car or operate machinery until you know how this medication affects you.
• remember that alcohol can add to the drowsiness caused by this medication.
• you should know that venlafaxine may cause high blood pressure. You should have your blood pressure checked before starting treatment and regularly while you are taking this medication.
• you should know that venlafaxine may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

What side effects can this medication cause?

Venlafaxine may cause side effects. Call your doctor if any of the following symptoms are severe or do not go away:

• drowsiness
• weakness or tiredness
• dizziness
• headache
• nightmares
• nausea
• vomiting
• stomach pain
• constipation
• diarrhea
• gas
• heartburn
• burping
• dry mouth
• change in ability to taste food
• loss of appetite
• weight loss
• uncontrollable shaking of a part of the body
• pain, burning, numbness, or tingling in part of the body
• yawning
• sweating
• hot flashes or flushing
• frequent urination
• difficulty urinating
• sore throat, chills, or other signs of infection
• ringing in the ears
• sexual problems in males; decreased sex drive, inability to get or keep an erection, or delayed or absent ejaculation
• sexual problems in females; decreased sex drive, or delayed orgasm or unable to have an orgasm
• enlarged pupils (black circles in the middle of the eyes)

Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS sections, call your doctor immediately:

• rash
• hives
• itching
• difficulty breathing or swallowing
• chest pain
• fast, pounding, or irregular heartbeat
• seizures
• unusual bruising or bleeding
• small purple spots on the skin
• fever, sweating, confusion, fast or irregular heartbeat, severe muscle stiffness or twitching, nausea, vomiting, or diarrhea
• problems with coordination
• hallucinations (seeing things or hearing voices that do not exist)
• coma (loss of consciousness for a period of time)

Venlafaxine may slow growth and weight gain in children. If your child is taking venlafaxine, your child's doctor will watch your child's growth carefully. Talk to your child's doctor about the risks of giving venlafaxine to your child.

Venlafaxine may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• dizziness
• nausea
• vomiting
• burning, tingling, or numbness of the hands and feet
• increased size of the pupil (black center of the eye)
• muscle pain
• hot and cold spells
• sleepiness
• seizures
• fast, slow, or irregular heartbeat
• coma (loss of consciousness for a period of time)

🔗 Reference: https://medlineplus.gov/druginfo/meds/a694020.html